Synthesis inhibitor containing ginsenoside of protein belonging to hsp 27 family

ジンセノサイド類含有hsp47合成抑制剤

Abstract

(57)【要約】 【課題】 コラーゲン合成を抑制することによって、細 胞外マトリックス産生の亢進の病態を示す病気を治療す ることができる、分子量47キロダルトンの熱ショック タンパク質の合成抑制剤を提供する。 【解決手段】 ジンセノサイド類を有効成分として含有 する。
PROBLEM TO BE SOLVED: To obtain the subject HSP47 synthesis inhibitor capable of suppressing collagen synthesis and treating diseases showing the condition of sthenia of extracellular matrix production, comprising a ginsenoside as an active ingredient. SOLUTION: Ginseng or koji is subjected to extraction treatment with water or an organic solvent and separated from impurities by filtration, centrifugal separation, etc., to give a crude extract, which is optionally purified by an adsorbent to give a ginsenoside (e.g. ginsenoside Rg1). Then, the ginsenoside is pharmaceutically manufactured alone or with an ordinary carrier to give the objective synthesis inhibitor which contains the ginsenoside as an active ingredient, has an inhibitory acton on synthesis of a heat shock protein (HSP47) having 47 kilodalton molecular weight, suppresses collagen synthesis in organs and is useful for treating diseases such as cirrhosis, interstitial lung disease, chronic renal insufficiency, hypertrophy of heart, postoperative cicatrice, burn cicatrice, keloid, scleroderma, arteriosclerosis, arthrorheumatism, etc.

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