Benzimidazoles et analogues associés en tant que modulateurs de sirtuine

Benzimidazoles and related analogs as sirtuin modulators

Abstract

Provided herein are sirtuin-modulating compounds of formula (II) The sirtuin-modulating compounds may be used for increasing the lifespan of a cell, and treating and/or preventing a wide variety of diseases and disorders including, for example, diseases or disorders related to aging or stress, diabetes, obesity, neurodegenerative diseases, cardiovascular disease, blood clotting disorders, inflammation, cancer, and/or flushing as well as diseases or disorders that would benefit from increased mitochondrial activity. Also provided are compositions comprising a sirtuin-modulating compound in combination with another therapeutic agent.
L'invention concerne des composés modulateurs de sirtuine de la formule (II). Les composés modulateurs de sirtuine peuvent être utilisés pour augmenter la durée de vie d'une cellule, et pour traiter et/ou prévenir une large variété de maladies et de troubles comprenant par exemple des maladies ou troubles associés au vieillissement ou au stress, le diabète, l'obésité, des maladies neurodégénératives, des maladies cardiovasculaires, des troubles de la coagulation du sang, une inflammation, le cancer et/ou des bouffées vasomotrices, ainsi que des maladies ou des troubles qui bénéficieraient d’une activité mitochondriale accrue. L'invention concerne également des compositions comportant un composé modulateur de sirtuine en combinaison avec un autre agent thérapeutique.

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