Methods of treating fibrotic diseases using tetrahydrocannabinol-11-oic acids

Procédé de traitement de maladies fibreuses mettant en œuvre des acides tétrahydrocannabinol-11-oïques

Abstract

This invention is in the field of medicinal chemistry and relates to novel compounds, and pharmaceutical compositions and methods of use thereof for the treatment and/or prevention of fibrotic diseases including scleroderma, systemic sclerosis, scleroderma-like disorders, sine scleroderma, liver cirrhosis, interstitial pulmonary fibrosis, Dupuytren's contracture, keloids, chronic kidney disease, chronic graft rejection, and other scarringlwound healing abnormalities, post operative adhesions, and reactive fibrosis. The invention also relates to methods of using the compounds and pharmaceutical compositions of this invention to treat fibrotic conditions.
La présente invention a trait au domaine de la chimie médicale et concerne de nouveaux composés, et des compositions pharmaceutiques et leurs procédés d'utilisation pour le traitement et/ou la prévention de maladies fibreuses comprenant la sclérodermie, la sclérose systémique, des troubles assimilés à la sclérodermie, la sclérodermie systémique, la cirrhose du foie, la fibrose pulmonaire interstitielle, la contracture de Dupuytren, les chéloïdes, la maladie rénale chronique, le rejet de greffe chronique, et d'autres anomalies de cicatrisation de plaies, des adhérences post-opératoires, et la fibrose réactive. L'invention concerne également des procédés d'utilisation des composés et des compositions pharmaceutiques selon l'invention pour traiter des états fibreux.

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NO-Patent Citations (3)

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Cited By (2)

    Publication numberPublication dateAssigneeTitle
    US-9801849-B2October 31, 2017Corbus Pharmaceuticals, Inc.Ultrapure tetrahydrocannabinol-11-oic acids
    US-9820964-B2November 21, 2017Corbus Pharmaceuticals, Inc.Ultrapure tetrahydrocannabinol-11-oic acids